pI: 8.462 |
Length (AA): 214 |
MW (Da): 24209 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 195 | 2bcg (Y) | 3 | 196 | 45.00 | 0 | 1 | 1.61 | -1.74 |
4 | 170 | 1z0a (A) | 3 | 170 | 82.00 | 0 | 1 | 1.91 | -2.43 |
1 | 176 | 2a5j (A) | 5 | 181 | 76.00 | 0 | 1 | 1.81783 | -1.91 |
8 | 209 | 5di3 (B) | 20 | 214 | 20.00 | 0 | 1 | 1.14633 | -0.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 Oocyst. | Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. | Gregory Hehl AB Sibley/Greg |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_128031)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G17170 | RAB GTPase homolog B1C |
Babesia bovis | BBOV_IV008990 | Rab2 |
Brugia malayi | Bm1_48090 | Ras-related protein Rab-2 |
Caenorhabditis elegans | CELE_F53F10.4 | Protein UNC-108 |
Cryptosporidium parvum | cgd1_2060 | Rab2 GTPase, putative |
Dictyostelium discoideum | DDB_G0292268 | Rab GTPase |
Drosophila melanogaster | Dmel_CG3269 | CG3269 gene product from transcript CG3269-RA |
Echinococcus granulosus | EgrG_000430800 | ras protein Rab 2A |
Entamoeba histolytica | EHI_046390 | Rab family GTPase |
Entamoeba histolytica | EHI_067850 | Rab family GTPase |
Echinococcus multilocularis | EmuJ_000430800 | ras protein Rab 2A |
Giardia lamblia | GL50803_16636 | Rab2b |
Giardia lamblia | GL50803_15567 | Rab2a |
Homo sapiens | ENSG00000104388 | RAB2A, member RAS oncogene family |
Homo sapiens | ENSG00000129472 | RAB2B, member RAS oncogene family |
Leishmania braziliensis | LbrM.32.2240 | ras-related protein rab-2a, putative |
Leishmania donovani | LdBPK_322160.1 | Ras-related protein RAB2B, putative |
Leishmania infantum | LinJ.32.2160 | ras-related protein rab-2a, putative |
Leishmania major | LmjF.32.2030 | ras-related protein rab-2a, putative |
Leishmania mexicana | LmxM.31.2030 | ras-related protein rab-2a, putative |
Loa Loa (eye worm) | LOAG_01691 | uncoordinated protein 108 |
Mus musculus | ENSMUSG00000022159 | RAB2B, member RAS oncogene family |
Mus musculus | ENSMUSG00000047187 | RAB2A, member RAS oncogene family |
Neospora caninum | NCLIV_055690 | hypothetical protein |
Oryza sativa | 4336117 | Os04g0470100 |
Oryza sativa | 4329809 | Os02g0586400 |
Plasmodium berghei | PBANKA_1445800 | ras-related protein Rab-2, putative |
Plasmodium falciparum | PF3D7_1231100 | ras-related protein Rab-2 |
Plasmodium knowlesi | PKNH_1450500 | ras-related protein Rab-2, putative |
Plasmodium vivax | PVX_124195 | ras-related protein Rab-2, putative |
Plasmodium yoelii | PY05254 | putative Rab2 GTPase |
Schistosoma japonicum | Sjp_0217140 | ko:K07878 Ras-related protein Rab-2B, putative |
Schistosoma japonicum | Sjp_0059440 | GTP-binding protein yptV4, putative |
Schistosoma japonicum | Sjp_0059430 | Ras-related protein Rab-2, putative |
Schistosoma mansoni | Smp_022810.1 | rab-2414 |
Schistosoma mansoni | Smp_022810.2 | rab-2414 |
Schistosoma mansoni | Smp_071630 | rab-2414 |
Schmidtea mediterranea | mk4.011455.00 | |
Schmidtea mediterranea | mk4.002573.02 | Ras-related protein Rab-25 |
Schmidtea mediterranea | mk4.003457.03 | |
Schmidtea mediterranea | mk4.007319.00 | |
Schmidtea mediterranea | mk4.000716.01 | |
Schmidtea mediterranea | mk4.004420.00 | |
Trypanosoma brucei gambiense | Tbg972.11.17120 | ras-related protein rab-2a, putative |
Trypanosoma brucei | Tb927.11.15240 | Ras-related protein RAB2B, putative |
Trypanosoma congolense | TcIL3000.11.15390 | Ras-related protein RAB2B, putative |
Trypanosoma cruzi | TcCLB.511711.80 | Ras-related protein RAB2B, putative |
Toxoplasma gondii | TGME49_312050 | small GTPase Rab2, putative |
Theileria parva | TP01_0877 | GTP-binding protein rab2, putative |
Trichomonas vaginalis | TVAG_527180 | RAB, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.6890 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.6890 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.6890 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.6890 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F53F10.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F53F10.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F53F10.4 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F53F10.4 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1445800 | Plasmodium berghei | Essential | plasmo |
TGME49_312050 this record | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2